In Vitro Metabolism of 4-Androstene-3,17-Dione by Human Submaxillary Gland Homogenates

Author:

Coffey James C.1,Crutchfield William C.1

Affiliation:

1. Dental Research Center, Departments of Pediatrics and Surgery, University of North Carolina, Chapel Hill, North Carolina 27514, USA

Abstract

Tritiated 4-androstene-3,17-dione was incubated with human submaxillary gland homoaenates. In 180-minute incubations, human submaxillary gland converted 4-androstene-3, 17-dione predominately to testosterone and to a lesser extent, 5α-androstane-3α,17β-diol and androsterone.

Publisher

SAGE Publications

Subject

General Dentistry

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