Basic Biological Sciences

Author:

Brownell Anna G.1,Rovero Linda J.1

Affiliation:

1. Laboratory for Developmental Biology, Department of Basic Sciences (Biochemistry Division), School of Dentistry, University of Southern California, Los Angeles, California 90007

Abstract

Developing enamel organ epithelium was cultured in the presence and absence of non-viable dental papilla mesenchyme cells. Epithelial cell proliferation was enhanced by 75% when cultivated on the mesenchyme cell substratum. The addition of epidermal growth factor (EGF) to enamel organ epithelium cultured on this substratum resulted in a synergistic enhancement of DNA synthesis.

Publisher

SAGE Publications

Subject

General Dentistry

Reference22 articles.

1. Inductive Epithelio-mesenchymal Interaction in Cultured Organ Rudiments of the Mouse

2. Slavkin, H.C.: Tooth Formation: A Tool in Developmental Biology, Oral Sciences Reviews 4 . Melcher, A. H. and Zarb, G. A., Eds. Copenhagen: Munksgaard, 1974, pp. 1-136.

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