Thin Layer Chromatography as a Routine Appropriate Technique for the Determination of Bipyridylium Herbicides in Post Mortem Human Tissues

Author:

Van Den Heede M.1,Heyndrickx A.2,Timperman J.3

Affiliation:

1. Senior Assistant, Department of Toxicology, Hospitaalstraat 13, B-9000 Ghent

2. Director, Department of Toxicology, Hospitaalstraat 13, B-9000 Ghent

3. Director, Department of Forensic Medicine, Prof. J. Kluyskensstraat 29, B-9000 Ghent State University of Ghent, Belgium

Abstract

A thin layer chromatographic procedure for the detection of bipyridylium compounds in post-mortem human tissues is described. To verify the suitability of the method, human biological samples originating from two fatal poisoning cases, are analyzed. In the first case, an amount of Gramoxone® (Paraquat) was taken orally. Death occurred after ± 30 hours without any specific treatment. The second case is concerned with an ingestion of Reglone® (Diquat), followed by death after 5 days of intensive care treatment.

Publisher

SAGE Publications

Subject

Law,Health Policy,Issues, ethics and legal aspects

Cited by 14 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Diagnostic Aspects of Paraquat in the Forensic Toxicology: A Systematic Review;Academic Forensic Pathology;2024-03-04

2. Acute diquat poisoning causes rhabdomyolysis;The American Journal of the Medical Sciences;2022-10

3. Lethal diquat poisoning manifesting as central pontine myelinolysis and acute kidney injury: A case report and literature review;Journal of International Medical Research;2020-07

4. Human and experimental toxicology of diquat poisoning: Toxicokinetics, mechanisms of toxicity, clinical features, and treatment;Human & Experimental Toxicology;2018-03-23

5. Herbicides;Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose;2007

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