Affiliation:
1. Department of Neurology, II School of Medicine, Naples, Italy
Abstract
A pharmacological trial has been carried out on 41 out-patients suffering from mixed headache. The prophylactic effect of a timed-release dihydroergotamine formulation was tested versus amitriptyline. Patients reported daily, on appropriate cards, the hours of headache and the degree of pain during the month before therapy and on the following two months of treatment. Whereas amitriptyline was found to be more effective than dihydroergotamine in reducing headache intensity, timed-release dihydroergotamine was found significantly more effective than amitriptyline in reducing attacks of “migraine” type. Les auteurs ont conduit une étude pharmacologique sur 41 patients souffrant de céphalée mixte. L'effet préventif de la dihydroergotamine à libération programmée a été comparé à celui de l'amitriptiline. Les patients ont quotidiennement enregistré, sur des fiches spéciales, les heures de céphalée et le degré d'intensité de la douleur au cours du mois précédant la thérapie et durant les deux mois de traitement. La dihydroergotamine à libération programmée s'est avérée de façon significative plus efficace que l'amitriptiline dans la réduction de la fréquence des attaques de type hémialgique. Gli autori hanno condotto uno studio farmacologico su 41 pazienti sofferenti di cefalea mista. L'effetto preventivo della diidroergotamina a liberazione programmata è stato paragonato a quello della amitriptilina. I pazienti hanno riportato, quotidianamente, su apposite schede, le ore di cefalea ed il grado di intensità del dolore nel mese precedente la terapia e durante i due mesi di trattamento. La diidroergotamina a liberazione programmata è risultata significativamente più efficace dell'amitriptilina nel ridurre la frequenza degli attacchi ti tipo emicranico.
Subject
Clinical Neurology,General Medicine
Cited by
6 articles.
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