Mandibular odontoameloblastoma in a rat and a horse

Author:

Murphy Brian123,Bell Cynthia123,Koehne Amanda123,Dubielzig Richard R.123

Affiliation:

1. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA (Murphy)

2. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, Madison, WI (Bell, Dubielzig)

3. Department of Comparative Medicine, School of Medicine, Stanford University, Stanford, CA (Koehne)

Abstract

Odontoameloblastoma (OA) is a mixed odontogenic tumor that is an ameloblastoma with concurrent histologic evidence of odontoma differentiation. As a mixed tumor, OA is a tripartite lesion comprised of neoplastic odontogenic epithelium, induced dental ectomesenchyme (dental pulp), and mineralized dental matrix. Although rare, OA represents a diagnostic conundrum, as it is histologically closely related to 2 other mixed odontogenic tumors: odontoma (complex and compound) and ameloblastic fibro-odontoma. Herein we describe an OA arising from the mandible of a 4-mo-old Fischer 344 rat that had been exposed in utero to the mutagen ENU (N-ethyl-N-nitrosourea), and a naturally occurring lesion in a 2-y-old Appaloosa horse. In order to satisfy the diagnostic criteria for this lesion, mineralized dental matrix in relationship to neoplastic odontogenic epithelium must be identifiable within the OA lesion. This group of odontogenic tumors is differentiated by the degree to which the dental matrix is organized and the relative proportions of pulp ectomesenchyme, odontogenic matrix, and odontogenic epithelium.

Publisher

SAGE Publications

Subject

General Veterinary

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