Postpartum clostridial gangrenous metritis in 12 dairy goats in France

Author:

Dorso Laëtitia12ORCID,Chartier Christophe1,Popoff Michel R.3,Tesson Cyrille4,Despres Jérôme5,Uzal Francisco A.6ORCID

Affiliation:

1. Oniris, INRAE (National Research Institute for Agriculture, Food and the Environment), BIOEPAR (Biology, Epidemiology and Risk Analysis in Animal Health), Nantes, France

2. Oniris, CHUV (University Veterinary Hospital), Nantes, France

3. Bacterial Toxins, Institut Pasteur, Paris, Cedex France

4. Réseau Cristal, Segré, France

5. Réseau Cristal, Cerizay, France

6. California Animal Health and Food Safety Laboratory System, San Bernardino Laboratory, School of Veterinary Medicine, University of California–Davis, Davis, CA, USA

Abstract

Clostridial infections in goats have been associated frequently with enteric diseases or gas gangrene but very rarely with the reproductive system. We describe here 12 cases of fatal postpartum gangrenous metritis in does associated with infection by several clostridial species. Clinically, these cases were characterized by rapid onset of hyperthermia followed by death after kidding. On postmortem examination, the uteri appeared to be necrotic and were hemorrhagic and edematous. Microscopically, the uteri had diffuse coagulative necrosis, edema, hemorrhage, and fibrinous thrombi with intralesional gram-positive rods. Clostridium perfringens was isolated from 7 of 9 uterine samples cultured, and C. perfringens, C. septicum, C. novyi, or C. chauvoei were demonstrated by immunohistochemistry (IHC) in the 5 cases examined. IHC for Paeniclostridium sordellii was negative in all 5 cases. PCR performed on 3 of the C. perfringens isolates was positive for alpha toxin and perfringolysin, identifying these isolates as type A. Clostridial infection should be considered in cases of postpartum gangrenous metritis of does.

Publisher

SAGE Publications

Subject

General Veterinary

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