Lipoprotein(a) Levels in Patients With Abdominal Aortic Aneurysm

Author:

Kotani Kazuhiko1,Sahebkar Amirhossein23,Serban Maria-Corina4,Ursoniu Sorin5,Mikhailidis Dimitri P.6,Mariscalco Giovanni7,Jones Steven R.8,Martin Seth8,Blaha Michael J.8,Toth Peter P.89,Rizzo Manfredi10,Kostner Karam11,Rysz Jacek12,Banach Maciej12,

Affiliation:

1. Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Japan

2. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3. Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

4. Discipline of Pathophysiology, Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

5. Discipline of Public Health, Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

6. Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London, London, United Kingdom

7. Department of Cardiovascular Sciences, University of Leicester Glenfield Hospital, Leicester, United Kingdom

8. The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA

9. Preventive Cardiology, CGH Medical Center, Sterling, IL, USA

10. Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy

11. Mater Hospital, University of Queensland, St Lucia, Australia

12. Department of Hypertension, Nephrology and Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Poland

Abstract

Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patients with AAA were found to have a significantly higher level of Lp(a) compared to the controls (SMD: 0.87, 95% CI: 0.41-1.33, P < .001). This result remained robust in the sensitivity analysis, and its significance was not influenced after omitting each of the included studies from the meta-analysis. The present meta-analysis confirmed a higher level of circulating Lp(a) in patients with AAA compared to controls. High Lp(a) levels can be associated with the presence of AAA, and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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