Natural History of Carotid Atherosclerosis in Relation to the Hemodynamic Environment-Reference-Cited by-同舟云学术

Natural History of Carotid Atherosclerosis in Relation to the Hemodynamic Environment

Published:2016-09-29 Issue:2 Volume:68 Page:109-118
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Sakellarios Antonis I.¹,Bizopoulos Paschalis¹,Papafaklis Michail I.²³⁴^ORCID,Athanasiou Lambros¹⁴⁵,Exarchos Themis¹⁶,Bourantas Christos V.⁷,Naka Katerina K.²³,Patterson Andrew J.⁸,Young Victoria E. L.⁸,Gillard Jonathan H.⁸,Parodi Oberdan⁹,Michalis Lampros K.²³,Fotiadis Dimitrios I.¹⁶

Affiliation:

1. Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science, University of Ioannina, Ioannina, Greece

2. Michailideion Cardiac Center, Medical School, University of Ioannina, Ioannina, Greece

3. Second Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece

4. Institute for Medical Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

5. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

6. Department of Biomedical Research Institute, Institute of Molecular Biology and Biotechnology, FORTH, University Campus of Ioannina, Ioannina, Greece

7. Department of Cardiovascular Sciences, University College London, London, United Kingdom

8. Department of Radiology, University of Cambridge, Cambridge, United Kingdom

9. Institute of Clinical Physiology, National Research Council, Pisa, Italy

Abstract

Carotid atherosclerosis may lead to devastating clinical outcomes such as stroke. Data on the value of local factors in predicting progression in carotid atherosclerosis are limited. Our aim was to investigate the association of local endothelial shear stress (ESS) and low-density lipoprotein (LDL) accumulation with the natural history of atherosclerotic disease using a series of 3 time points of human magnetic resonance data. Three-dimensional lumen/wall reconstruction was performed in 12 carotids, and blood flow and LDL mass transport modeling were performed. Our results showed that an increase in plaque thickness and a decrease in lumen size were associated with low ESS and high LDL accumulation in the arterial wall. Low ESS (odds ratio [OR]: 2.99; 95% confidence interval [CI]: 2.31-3.88; P < .001 vs higher ESS) and high LDL concentration (OR: 3.26; 95% CI: 2.44-4.36; P < .001 vs higher LDL concentration) were significantly associated with substantial local plaque growth. Low ESS and high LDL accumulation both presented a diagnostic accuracy of 67% for predicting plaque growth regions. Modeling of blood flow and LDL mass transport show promise in predicting progression of carotid atherosclerosis.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319716644138

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