Development of a Medication-Use Evaluation Template for Andexanet Alfa in the Reversal of Anticoagulation With Factor Xa Inhibitors

Author:

Fera Toni1,Burnett Allison2,Grandoni Jessica3,Moore Mary R.4,Nussbaum Barbara B.5,Pollack Charles V.6,Rose Anne E.7,Spinler Sarah A.8,Streiff Michael B.9,Turck Charles J1011ORCID,Fanikos John12

Affiliation:

1. Project Consultant, Greater Pittsburgh Area, PA, USA

2. Inpatient Antithrombosis Stewardship Service, University of New Mexico Hospital, Albuquerque, NM, USA

3. Department of Pharmacy, Brigham and Women’s Hospital, Boston, MA, USA

4. Mass General Brigham, Boston, MA, USA

5. ASHP Research and Education Foundation, Bethesda, MD, USA

6. Department of Emergency Medicine, University of Mississippi, Jackson, MS, USA

7. Department of Pharmacy, UW Health, Madison, WI, USA

8. Department of Pharmacy Practice, Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, NY, USA

9. Department of Medicine, Division of Hematology, The Johns Hopkins University, Baltimore, MD, USA

10. Scientia Perpetuam, LLC, Greater Chicago Area, IL, USA

11. ScientiaCME, Inc., Los Angeles, CA, USA

12. North American Thrombosis Forum, Brookline, MA, USA

Abstract

Medication-use evaluations are meant to ensure that medication-use processes are consistent with prevailing standards of care, assure optimal use of therapy, and reduce the risk of medication-related problems. Reversal agents for direct oral anticoagulants are a worthy focus for medication-use evaluations for reasons of efficacy, safety, and cost. A multidisciplinary team of experts developed 2 medication-use evaluation templates illustrating the application of professional society guidelines to the appropriate use of andexanet alfa.

Funder

Alexion, AstraZeneca Rare Disease

Publisher

SAGE Publications

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