Affiliation:
1. Division of Gerontology and Geriatrics, Institute of Special Medical Pathology, University of Siena, Siena, Italy
Abstract
Cyclandelate, a vasoactive substance consisting of the mandelic acid ester of 3,3,5-trimethylcyclohexanol, was administered to 10 patients with cerebrovascular and/or peripheral vascular disease. Blood specimens were collected at 1 − 6 h after oral administration of 1600 mg cyclandelate, and the ester and acid were extracted from plasma in acid medium using n-hexane/isopropyl alcohol. The concentrations were determined by a high-performance liquid chromatography isocratic system. The highest plasma cyclandelate concentrations were detected at the third hour, whereas plasma mandelic acid concentrations were still increasing 6 h after administration.
Subject
Biochemistry (medical),Cell Biology,Biochemistry,General Medicine
Cited by
1 articles.
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1. C;Hagers Handbuch der Pharmazeutischen Praxis;1993