Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study

Author:

Mohamed Ali Sameera1ORCID,Musa Anas1,Omar Muhammed Khalifa1,Javed Sumbul1,Al Raqabani Mohamed1,Adnan Baradie Basem1,Sobhi Gargousa Marian1,Osman Oghowan AbdelRahman1,AlDeen Roqia Salah1,Lakshmanan Jeyaseelan2,Al Hashemi Haitham1,Omar Baslaib Fahad1

Affiliation:

1. Rashid Hospital, Dubai, U.A.E.

2. Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, U.A.E.

Abstract

Objective To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. Methods A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality. Results A prolonged QTc interval >450 ms was found in 27% of patients admitted with SARS-CoV-2 infection. These patients were predominantly older, on a ventilator, and had hypertension, diabetes mellitus, or ischemic heart disease. They also had high troponin and D-dimer concentrations. A prolonged QTc interval had a significant association with the requirement of ventilator support and was associated with an increased odds of mortality. Patients who died were older than 55 years, and had high troponin, D-dimer, creatinine, procalcitonin, and ferritin concentrations, a high white blood cell count, and abnormal potassium concentrations (hypo- or hyperkalemia). Conclusions A prolonged QTc interval is common in patients with SARS-CoV-2 infection and it is associated with worse outcomes. Older individuals and those with comorbidities should have an electrocardiogram performed, which is noninvasive and easily available, on admission to hospital to identify high-risk patients.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

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