Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers

Author:

Heffernan Kevin S1,Karas Richard H2,Patvardhan Eshan A3,Kuvin Jeffrey T3

Affiliation:

1. Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA, , Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA, USA, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA

2. Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA, Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA, USA, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA

3. Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA, Department of Medicine, Division of Cardiology

Abstract

Smoking is an established cardiovascular risk factor that impairs endothelial function and reduces exercise capacity. Peripheral vascular endothelial function correlates with exercise capacity, but whether this association prevails in smokers is unknown. The purpose of this investigation was to examine the association between endothelial function and exercise capacity in chronic smokers and non-smoking controls. Brachial artery flow-mediated dilation (FMD, endothelium-dependent) following 5 minutes of upper arm occlusion was compared in 26 smokers (age 58 ± 2 years; 15 female; BMI (body mass index) = 28 ± 1) and 39 non-smokers (age 58 ± 2 years; 24 female; BMI = 28 ± 1) using ultrasound. Exercise treadmill time (ETT) was recorded from a standard Bruce protocol during symptom limited stress testing. There was found to be a significant positive association between FMD and ETT in smokers ( r = 0.60, p < 0.05) and non-smokers ( r = 0.28, p < 0.05). FMD was significantly lower in smokers versus non-smokers (8.9 ± 0.9 vs 12.6 ± 0.7%, p < 0.05). ETT was significantly lower in smokers (425 ± 35 seconds) versus non-smokers (522 ± 25 seconds, p < 0.05). After adjusting for FMD, there were no longer group differences in ETT. When patients were matched according to FMD, there were no differences in ETT between smokers and non-smokers. In conclusion, peripheral endothelial dysfunction is a correlate of low exercise capacity in smokers and non-smokers alike. Future research is needed to examine if improving endothelial function will lead to concomitant increases in exercise capacity in chronic smokers.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3