Polycomponent Ophthalmic Inserts with Polysaccharide Support-Reference-Cited by-同舟云学术

Polycomponent Ophthalmic Inserts with Polysaccharide Support

Published:1988-10 Issue:4 Volume:3 Page:370-389
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Dumitriu Severian¹,Popa Marcel¹,Vancea Petre²,Costin Danut²

Affiliation:

1. Polytechnic Institute of Jassy Department of Organic and Macromolecular Chemistry 23 August 11, R-6600, Jassy, Romania

2. Institute of Medicine and Pharmacy Universitatii 15 R-6600, Jassy, Romania

Abstract

Ophthalmic inserts, based on xanthane modified with pilocarpine, adrena line and hydrocortisone have been prepared. The drugs were fixed in the insert by ionic bonds and gel entrapment. The in vitro release rate of pilocarpine de pended on the degree of xanthane modification and on the drug content in the polymer matrix. Inserts show a high ophthalmic tolerance indicating the potential for treatment of glaucoma.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391158800300404

Reference18 articles.

1. Urquhart, J. "Development of the Ocusert®," in Ophthalmic Drug Delivery Systems. Y R. Robinson, ed. Washington, D.C.:American Pharmaceutical Association , p. 105 ( 1980).

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