Controlled Release of 17β-Estradiol from d,l-Lactide/ε-Caprolactone Copolymers-Reference-Cited by-同舟云学术

Controlled Release of 17β-Estradiol from d,l-Lactide/ε-Caprolactone Copolymers

Published:1996-04 Issue:2 Volume:11 Page:110-121
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Buntner Barbara¹,Nowak Mariusz¹,Bero Maciej²,Dobrzyiiski Piotr²,Kasperczyk Janusz²

Affiliation:

1. Department of Pathophysiology, Silesian University, School of Medicine, 41-800, Zabrze, Poland

2. Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

Abstract

A study of the release of β-estradiol from d,l-lactide/ε-caprolactone copolymers was performed. The copolymers were used in the form of films (in vitro) and microspheres (in vivo). The dl-lactide content was varied from 50 to 94% in the copolymers studied. It was found that an almost constant rate of β-estradiol release for about 70 days can be achieved by the application of appropriately selected material.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391159601100203

Reference31 articles.

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3. 4. Davis, S. S. and L. Illum. 1984. Microspheres and Drug Therapy Pharmaceutical Immunological and Medical., J. G. Mc. E. Tomlinhson, eds. Amsterdam: Elsevier, p. 97.

4. Synthesis of Biodegradable Polymers for Biomedical Utilization

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