Affiliation:
1. A.V Topchiev Institute of Petrochemical Synthesis of Russian Acad. Sci. Leninsky Prospect 29 Moscow 117071, Russia
Abstract
A new approach to the targeted thermally activated transport of chemical agents and physiologically active compounds is reported. The method involves the immobilization of these compounds on a water-soluble polymer with a low critical solution temperature and heating the delivery site above the critical temperature. The approach was illustrated with trypsin immobilized on N-isopropylacrylamide-acrylamide- N-acryloylphthalimide ternary copoly mers.
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering
Cited by
22 articles.
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