Cell Growth on Immobilized Cell-Growth Factor. Interactions of Fibroblast Cells with Insulin Immobilized on 2-Hydroxyethyl Methacrylate /Ethyl Methacrylate Copolymer Membranes-Reference-Cited by-同舟云学术

Cell Growth on Immobilized Cell-Growth Factor. Interactions of Fibroblast Cells with Insulin Immobilized on 2-Hydroxyethyl Methacrylate /Ethyl Methacrylate Copolymer Membranes

Published:1994-04 Issue:2 Volume:9 Page:170-183
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Ito Yoshihiro¹,Shu Qin Liu ¹,Orihara Tamotsu¹,Imanishi Yukio¹

Affiliation:

1. Department of Polymer Chemistry Faculty of Engineering Kyoto University Sakyo-ku, Kyoto 606-01, Japan

Abstract

The adhesion and growth of mouse fibroblast cells STO were in vestigated in the presence of 2-hydroxyethyl methacrylate/ethyl methacrylate copolymer membranes with immobilized insulin. For the copolymer membrane without immobilized insulin, cell adhesion and growth were moderately sup pressed, on those copolymer membranes containing very high or very low 2-hydroxyethyl methacrylate content. A similar effect by the copolymer compo sition was observed on the membranes immobilized with small amounts of in sulin. Large amounts of immobilized insulin remarkably enhanced cell growth and masked the copolymer composition effects. The immobilized insulin en hanced the cell growth more than free insulin.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391159400900204

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