Successful treatment with secnidazole for trichomoniasis in the setting of metronidazole hypersensitivity

Author:

Kufel Wesley D123ORCID,Asiago-Reddy Elizabeth A23,Parsels Katie A3,Sanyal Soma23,Coyne Jennifer L23

Affiliation:

1. Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, NY, USA

2. State University of New York Upstate Medical University, Syracuse, NY, USA

3. State University of New York Upstate University Hospital, Syracuse, NY, USA

Abstract

Limited effective treatment options currently exist for trichomoniasis management among patients with metronidazole hypersensitivity. We report a patient with a documented history of metronidazole hypersensitivity who initially was treated with nitazoxanide but demonstrated clinical and microbiological failure. Secnidazole was subsequently used for treatment, which resulted in clinical and microbiological cure without observation of cross-reactivity. Secnidazole may represent a potential treatment option for trichomoniasis in patients with metronidazole hypersensitivity after consultation with an infectious disease specialist.

Funder

Merck and Melinta Therapeutics

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

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