Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infection and associated factors among asymptomatic pregnant women in Botswana

Author:

Mussa Aamirah12ORCID,Wynn Adriane3,Ryan Rebecca1,Babalola Chibuzor M4,Hansman Emily15ORCID,Simon Selebaleng1,Bame Bame1,Tamuthiba Lefhela1,Ramontshonyana Kehumile1,Ndlovu Neo1,Moshashane Neo1,Masole Maitumelo1,Klausner Jeffrey D4ORCID,Morroni Chelsea16

Affiliation:

1. Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana

2. Usher Institute, University of Edinburgh, Edinburgh, UK

3. Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA

4. University of Southern California, Los Angeles, CA, USA

5. University of California, Los Angeles, CA, USA

6. MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

Abstract

Background Chlamydia trachomatis ( C. trachomatis) and Neisseria gonorrhoeae ( N. gonorrhoeae) are curable sexually transmitted infections (STIs) that cause adverse pregnancy and neonatal outcomes. Most countries, including Botswana, do not offer C. trachomatis or N. gonorrhoeae screening during antenatal care (ANC) and instead use a syndromic approach for management of STIs. Methods The Maduo Study is a prospective, cluster-controlled trial in Botswana evaluating the impact of diagnostic screening for antenatal C. trachomatis and N. gonorrhoeae infections to prevent adverse neonatal outcomes. Using baseline data from the Maduo Study (March 2021–March 2022), we determined the prevalence of C. trachomatis and N. gonorrhoeae infection among asymptomatic pregnant women in Botswana and correlates of infection using multivariable logistic regression. Results Of 251 women who underwent C. trachomatis and N. gonorrhoeae screening at first ANC visit, 55 (21.9%, 95%CI 17.0–27.5) tested positive for C. trachomatis, 1 (0.4%, 95%CI 0–2.2) for N. gonorrhoeae; and 2 (0.8%, 95%CI 0–2.8) for dual C. trachomatis and N. gonorrhoeae infection. Older age was associated with lower odds (aOR 0.93; 95%CI 0.88–0.98; p = 0.011) while any alcohol use during pregnancy was associated with higher odds (aOR = 3.53; 95%CI 1.22–10.16; p = 0.020) of testing positive for C. trachomatis or N. gonorrhoeae. Conclusions A high frequency of C. trachomatis infections was detected among asymptomatic pregnant women in Botswana indicating that many antenatal STIs are missed by the syndromic management approach. Our results highlight the need for diagnostic C. trachomatis screening during ANC in Botswana and other low- and middle-income countries that rely solely on the syndromic approach for management of STIs.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3