Adherence, Effectiveness and Safety of Dolutegravir Based Antiretroviral Regimens among HIV Infected Children and Adolescents in Tanzania

Author:

Mutagonda Ritah F.1ORCID,Mlyuka Hamu J.1,Maganda Betty A.2,Kamuhabwa Appolinary A. R.1ORCID

Affiliation:

1. Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania

2. Department of Pharmaceutics and Pharmacy practice, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania

Abstract

Objectives:This study aimed at assessing adherence, effectiveness, and safety of DTG-based HAART regimens among HIV-infected children and adolescents in Tanzania. Methods: This was a single-center prospective cohort study, conducted at the pediatric HIV Clinic in Mbeya, Tanzania. A binary logistic regression model was used to determine predictors of undetectable viral load at week 24. The results were significant when P-value was <0.05. Results: A total of 200 patients were enrolled with the majority (85.5%) being treatment experienced. High adherence levels (71%) were observed using the pharmacy refill method. At week 24, the overall proportion of patients with undetectable viral load was 70.2%. The predictors of undetectable viral load were age, World Health Organization (WHO) clinical stage, baseline VL and adherence to pharmacy refill. Conclusion: The majority of patients attained undetectable viral load 6 months after using DTG based regimen. DTG-based regimens were generally safe with few ADEs reported.

Funder

MUHAS-SIDA seed grant for junior faculty

Publisher

SAGE Publications

Subject

Infectious Diseases,Dermatology,Immunology

Reference48 articles.

1. UNICEF. Global and Regional trends 2019; https://data.unicef.org/topic/hivaids/globalregional-trends/. Accessed on 17th December 2021.

2. United Republic of Tanzania. Country Profile. UNAIDS Data. Joint United Nations Programme on HIV/AIDS 2018. http://www.unaids.org/en/resources/documents/2018/unaids-data-2018. Accessed on 17th December 2021.

3. Tanzania HIV Impact Survey (THIS). A population-based HIV impact assessment 2016-2017. January 2018. https://www.nbs.go.tz/nbs/takwimu/this2016-17/Tanzania_SummarySheet_English.pdf. Accessed on 17th December 2021.

4. World Health Organization. Global Health Observatory (GHO) data. HIV/ AIDS 2018; https://www.who.int/gho/hiv/en/. Accessed on 17th December 2021.

5. Dorward J, Lessells R, Drain PK, et al. Dolutegravir for first-line antiretroviral therapy in low- and middle-income countries: uncertainties and opportunities for implementation and research. Accessed on 17th December 2021.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3