Lambert–Eaton myasthenic syndrome revealed after surgery of lung adenocarcinoma

Author:

Kabiri El Hassane12ORCID,Hammoumi Massine El1ORCID,Sbitti Yassir2

Affiliation:

1. Department of Thoracic Surgery, Department of Medical Oncology, Mohammed V Military Teaching Hospital, Rabat Morocco

2. Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat Morocco

Abstract

We report a very rare case of cT1N0M0 lung adenocarcinoma reveling Lambert-Eaton myasthenic syndrome (LEMS). A 69-year-old nonsmoking woman, with several comorbidities consulted for cough and dyspnea. Chest radiograph and CT scanning detected a left lower lobe mass; Needle biopsy confirmed differentiated adenocarcinoma; 18FDG-PET scan and Brain MRI eliminated metastatic disease dissemination. Our patient underwent a left lower lobectomy with mediastinal lymphadenectomy (pT1N0M0), no adjuvant chemotherapy was administrated. One month later patient present a muscle weakness in both lower limbs and fatigability followed by an inability to walk. The diagnosis of LEMS was made from the distinctive electromyogram (EMG) findings and a treatment with Amifampridine (3, 4-diaminopyridine phosphate [3, 4-DAP]) was prescribed with evident efficacy for symptoms.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,General Medicine,Surgery

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