Well-Differentiated Lymphocytic Leukemia in a Dog: Long-Term Survival Without Therapy

Author:

Harvey J. W.1,Terrell T. G.1,Hyde D. M.1,Jackson R. I.1

Affiliation:

1. College of Veterinary Medicine, University of Florida, Gainesville, Fla. and Parkway Animal Hospital, Jacksonville, Fla.

Abstract

Well-differentiated lymphocytic leukemia was found during routine hematologic examination of a 12-year-old female poodle with signs of anxiousness, panting and pica. The total white blood cell count was 106,900/μ1 and at least 90% of the leukocytes were small, normal-appearing lymphocytes. The dog was examined several times during a 23-month period before it was killed at the owner's request for conditions unrelated to the leukemia. The hematologic picture of the leukemia was essentially unchanged during this time. A deep nuclear cleft was seen in most lymphocytes examined by electron microscopy. Cell surface markers showed most blood lymphocytes to be B-cells. These cells responded poorly to mitogen stimulation.

Publisher

SAGE Publications

Subject

General Veterinary

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1. Rapid clinical progression of B-cell chronic lymphocytic leukemia in a horse;Journal of the American Veterinary Medical Association;2019-09-15

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3. Tumors of the Hemolymphatic System;Tumors in Domestic Animals;2016-11-12

4. Hematopoietic Tumors;Withrow and MacEwen's Small Animal Clinical Oncology;2013

5. Immunophenotype Predicts Survival Time in Dogs with Chronic Lymphocytic Leukemia;Journal of Veterinary Internal Medicine;2010-11-23

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