Kinetics of Methaemoglobin Production (2). Kinetics of the Cyanide Antidote p-Aminopropiophenone During Oral Administration

Author:

Bright J.E.1,Marrs T.C.1

Affiliation:

1. Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK

Abstract

The kinetics of methaemoglobin production by orally administered p-aminopropiophenone (PAPP) was studied by using a kinetic model previously developed to describe methaemoglobinaemia consequent on intravenous injection of PAPP. Both ISIS, a simulation package, and NONLIN, a non-linear least-squares regression analysis program, were used to analyse the data. Some modification of the model was necessary to describe oral profiles and 40-50% of the administered PAPP appeared to be being metabolized at first pass to a non-active metabolite.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference12 articles.

1. A comparison of the methemoglobin-inducing activity of moderate oral doses of 4-dimethylaminophenol and p-aminopropiophenone

2. Synthesis and biologic activity of p-hydroxylaminopropiophenone

3. Downey, R.L. (1966). Radiation protection and methemoglobin-formation related to the metabolism of p-aminopropiophenone. PhD thesis, University of Indiana, pp. 59-61.

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