Affiliation:
1. Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Abstract
The kinetics of methaemoglobin production by orally administered p-aminopropiophenone (PAPP) was studied by using a kinetic model previously developed to describe methaemoglobinaemia consequent on intravenous injection of PAPP. Both ISIS, a simulation package, and NONLIN, a non-linear least-squares regression analysis program, were used to analyse the data. Some modification of the model was necessary to describe oral profiles and 40-50% of the administered PAPP appeared to be being metabolized at first pass to a non-active metabolite.
Subject
Health, Toxicology and Mutagenesis,Toxicology
Cited by
9 articles.
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