Endothelial microparticles: Sophisticated vesicles modulating vascular function-Reference-Cited by-同舟云学术

Endothelial microparticles: Sophisticated vesicles modulating vascular function

Published:2013-07-26 Issue:4 Volume:18 Page:204-214
ISSN:1358-863X
Container-title:Vascular Medicine
language:en
Short-container-title:Vasc Med

Author:

Curtis Anne M¹,Edelberg Jay²,Jonas Rebecca³,Rogers Wade T³,Moore Jonni S³,Syed Wajihuddin⁴,Mohler Emile R⁴

Affiliation:

1. Trinity Biomedical Science Institute (TBSI), Dublin, Ireland

2. Sanofi-aventis, Bridgewater, NJ, USA

3. Department of Pathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

4. Department of Medicine, Division of Cardiovascular Disease, Section of Vascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

Abstract

Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1358863X13499773

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