Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson’s Disease

Author:

Gonçalves Valeria C.123,Cuenca-Bermejo Lorena12,Fernandez-Villalba Emiliano12,Martin-Balbuena Sebastian12,da Silva Fernandes Maria Jose3,Scorza Carla A.3,Herrero Maria-Trinidad12ORCID

Affiliation:

1. Clinical & Experimental Neuroscience (NiCE), Biomedical Research Institute of Murcia (IMIB- Arrixaca), Murcia, Spain

2. Clinical & Experimental Neuroscience (NiCE), Institute for Ageing Research (IUIE), School of Medicine, Campus Mare Nostrum. University of Murcia, Murcia, Spain

3. Disciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil

Abstract

It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson’s disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way to prevent the disease from its progressive nature yet and only its symptoms can be minimized. It is known that the process of neurodegeneration begins before the onset of motor signs and symptoms of the disease, when diagnosis is usually made. Therefore, recognizing manifested non-motor symptoms can make an early diagnosis possible and lead to a better understanding of the disease. Autonomic dysfunctions are important non-motor manifestations of Parkinson’s disease and affect the majority of patients. Importantly, heart failure is the third leading cause of death in people suffering from Parkinson’s disease. Several evidences have shown the correlation between Parkinson’s disease and the preexistence of cardiovascular diseases. Therefore, cardiovascular monitoring and identification of its dysfunctions can have a prodromal role for Parkinson’s disease. This review presents studies of the literature that can lead to a better understanding of Parkinson’s disease with special attention to its relation to heart and cardiovascular parameters.

Funder

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior

Ministerio de Ciencia e Innovacion

Fundacion Seneca

Publisher

SAGE Publications

Subject

Clinical Neurology,General Neuroscience

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