Late-Onset Epileptogenesis and Seizure Genesis: Lessons From Models of Cerebral Ischemia-Reference-Cited by-同舟云学术

Late-Onset Epileptogenesis and Seizure Genesis: Lessons From Models of Cerebral Ischemia

Published:2007-10-02 Issue:1 Volume:14 Page:78-90
ISSN:1073-8584
Container-title:The Neuroscientist
language:en
Short-container-title:Neuroscientist

Author:

Epsztein Jérôme¹,Ben-Ari Yehezkel¹,Represa Alfonso¹,Crépel Valérie²

Affiliation:

1. INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 29), and Université de La Méditerranée, Marseille Cedex, France

2. INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 29), and Université de La Méditerranée, Marseille Cedex, France,

Abstract

Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis. NEUROSCIENTIST 14(1):78—90, 2008.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1073858407301681

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