Disposition Kinetics and Tolerance of Escalating Single Doses of Ramelteon, a High-Affinity MT1and MT2Melatonin Receptor Agonist Indicated for Treatment of Insomnia

Author:

Karim Aziz,Tolbert Dwain,Cao Charlie

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist;Kato;Neuropharmacology,2005

2. A safety, tolerance, and pharmacokinetic study of five single doses of TAK-375 in healthy adults [abstract];Stubbs;Sleep,2003

3. A phase-I open-label study of the absorption, metabolism, and excretion of (14C)-ramelteon (TAK-375) following a single oral dose in healthy male subjects [abstract];Hibberd;Sleep,2004

4. A phase I study to investigate the absolute bioavailability of a single oral dose of ramelteon (TAK-375) in healthy male subjects [abstract];Amakye;Sleep,2004

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