Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects With Psoriasis and With Type 1 Diabetes Mellitus-Reference-Cited by-同舟云学术

Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects With Psoriasis and With Type 1 Diabetes Mellitus

Published:2010-05 Issue:5 Volume:50 Page:494-506
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:

Author:

Wiczling Paweł,Rosenzweig Michael,Vaickus Louis,Jusko William J.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1177/0091270009349376/fullpdf

Reference70 articles.

1. The T cell receptor: structural and functional studies;Geisler;Dan Med Bull,1995

2. T cell antigen receptor signal transduction pathways;Cantrell;Cancer Surv,1996

3. Signal transduction by the TCR for antigen;Kane;Curr Opin Immunol,2000

5. The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties;Bolt;Eur J Immunol,1993

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