Cell Adhesion Molecules in Inflammation and Immunity: Relevance to Periodontal Diseases

Author:

Crawford John M.1,Watanabe Keiko2

Affiliation:

1. Department of Periodontics and Center for Research in Oral Molecular Biology, University of Illinois at Chicago College of Dentistry, 801 South Paulina Street, Chicago, IL 60612

2. Department of Periodontics, University of Illinois at Chicago College of Dentistry, 801 South Paulina Street, Chicago, IL 60612

Abstract

Inflammatory and immune responses involve close contact between different populations of cells. These adhesive interactions mediate migration of cells to sites of inflammation and the effector functions of cells within the lesions. Recently, there has been significant progress in understanding the molecular basis of these intercellular contacts. Blocking interactions between cell adhesion molecules and their ligands has successfully suppressed inflammatory reactions in a variety of animal models in vivo. The role of the host response in periodontal disease is receiving renewed attention, but little is known of the function of cell adhesion molecules in these diseases. In this review we summarize the structure, distribution, and function of cell adhesion molecules involved in inflammatory/immune responses. The current knowledge of the distribution of cell adhesion molecules is described and the potential for modulation of cell adhesion molecule function is discussed.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Reference212 articles.

1. Altieri, D.C.: Occupancy of CD1 lb/CD18 (Mac-1) Divalent Ion Binding Site(s) Induces Leukocyte Adhesion. J. Immunol. 147:1891-1896 (1991 ).

2. Altieri, D.C. and T.S. Edington: The Saturable High Affinity Association of Factor X to ADP-Stimulated Monocytes Defines a Novel Function of the Mac-1 Receptor. J. Biol. Chem. 263:7007-7015 (1988).

3. Altieri, D.C. and T.S. Edington: A Monoclonal Antibody Reacting with Distinct Adhesion Molecules Defines a Transition in the Functional State of the Receptor CDllb/CD18 (Mac-1). J. Immunol. 141:2656-2660 (1988 ).

4. Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade.

5. Abnormal mobility of neonatal polymorphonuclear leukocytes. Relationship to impaired redistribution of surface adhesion sites by chemotactic factor or colchicine.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3