Affiliation:
1. Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908
Abstract
Intracellular transport and secretion of salivary proteins are major activities of salivary acinar cells. While the major intracellular pathway followed by salivary proteins following their synthesis has been described previously, there is only limited understanding of how this process is regulated at the molecular level. Studies of salivary proteins, especially proline-rich proteins, expressed in an endocrine cell line have begun to provide insight regarding intermolecular interactions during transport and the role played by structural signals during intracellular sorting. Analysis of the secretion of newly synthesized salivary proteins in parotid tissue has shown that there are multiple pathways of discharge from acinar cells. While granule exocytosis is the major pathway, at least two other pathways that export salivary proteins have been found to originate from maturing secretion granules. These pathways may contribute to other acinar cell functions, including secretion of proteins in the absence of acute stimulation and support of the secretory process for fluid and electrolytes.
Subject
General Dentistry,Otorhinolaryngology
Reference126 articles.
1. DYNAMIC CHANGES IN THE ULTRASTRUCTURE OF THE ACINAR CELL OF THE RAT PAROTID GLAND DURING THE SECRETORY CYCLE
2. Influence of circulating catecholamines on protein secretion into rat parotid saliva during parasympathetic stimulation.
3. A view of acidic intracellular compartments.
4. Ann DK, Carlson DM (1985). The structure and organization of a proline-rich protein gene of a mouse multigene family. J Biol Chem 260:15863-15872.
5. Ann DK, Clements S., lohnstone EM, Carlson DM (1987). Induction of tissue specific proline-rich protein multigene families in rat and mouse parotid glands by isoproterenol. Unusual strain differences of proline-rich protein mRNAs. J Biol Chem 262:899-904.
Cited by
97 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献