Current Status of Histogenetic and Morphogenetic Concepts of Salivary Gland Tumorigenesis-Reference-Cited by-同舟云学术

Current Status of Histogenetic and Morphogenetic Concepts of Salivary Gland Tumorigenesis

Published:1993-10 Issue:5 Volume:4 Page:639-677
ISSN:1045-4411
Container-title:Critical Reviews in Oral Biology & Medicine
language:en
Short-container-title:Critical Reviews in Oral Biology & Medicine

Author:

Dardick Irving¹,Burford-Mason Aileen P.²

Affiliation:

1. Department of Pathology, Banting Institute, University of Toronto, 100 College Street, Toronto, Ontario M5G 1 L5, Canada

2. Conacher Laryngeal Laboratory, The Toronto Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada

Abstract

Because of their complexity and relative infrequency, salivary gland tumors commonly result in diagnostic problems. Histogenetic and morphogenetic concepts of tumorigenesis in these glands are reviewed and their relevance to routine diagnosis and classification of salivary gland tumors evaluated. Evidence is presented from animal and human studies that under steady-state and pathophysiological conditions, all cell types present in the normal gland, including acinar cells, are capable of rapidly entering the cell cycle and are, therefore, possible targets for neoplastic transformation.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/10454411930040050201

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