Reproducibility of Published Meta-Analyses on Clinical-Psychological Interventions

Abstract

Meta-analysis is one of the most useful research approaches, the relevance of which relies on its credibility. Reproducibility of scientific results could be considered as the minimal threshold of this credibility. We assessed the reproducibility of a sample of meta-analyses published between 2000 and 2020. From a random sample of 100 articles reporting results of meta-analyses of interventions in clinical psychology, 217 meta-analyses were selected. We first tried to retrieve the original data by recovering a data file, recoding the data from document files, or requesting it from original authors. Second, through a multistage workflow, we tried to reproduce the main results of each meta-analysis. The original data were retrieved for 67% (146/217) of meta-analyses. Although this rate showed an improvement over the years, in only 5% of these cases was it possible to retrieve a data file ready for reuse. Of these 146, 52 showed a discrepancy larger than 5% in the main results in the first stage. For 10 meta-analyses, this discrepancy was solved after fixing a coding error of our data-retrieval process, and for 15 of them, it was considered approximately reproduced in a qualitative assessment. In the remaining meta-analyses (18%, 27/146), different issues were identified in an in-depth review, such as reporting inconsistencies, lack of data, or transcription errors. Nevertheless, the numerical discrepancies were mostly minor and had little or no impact on the conclusions. Overall, one of the biggest threats to the reproducibility of meta-analysis is related to data availability and current data-sharing practices in meta-analysis.