The Effects of Sevoflurane on Isolated Gravid Human Myometrium-Reference-Cited by-同舟云学术

The Effects of Sevoflurane on Isolated Gravid Human Myometrium

Published:2002-10 Issue:5 Volume:30 Page:591-596
ISSN:0310-057X
Container-title:Anaesthesia and Intensive Care
language:en
Short-container-title:Anaesth Intensive Care

Author:

Turner R. J.¹²,Lambros M.¹³,Holmes C.¹⁴,Katz S. G.¹⁵,Downs C. S.¹⁶,Collins D. W.¹⁷,Gatt S. P.¹⁸

Affiliation:

1. Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia

2. Lecturer, The University of New South Wales, Prince of Wales Hospital, Sydney, Australia.

3. St George Hospital, Sydney, Australia.

4. The Canberra Hospital, Canberra, Australia.

5. Director of Anaesthesia, Royal Hospital for Women, Sydney, Australia.

6. Visiting Medical Officer, Sydney Childrens Hospital, Royal Hospital for Women, Sydney, Australia.

7. Sydney Children's Hospital, Sydney, Australia.

8. Department of Anaesthesia, Prince of Wales Hospital, Sydney, Australia.

Abstract

The volatile anaesthetic agents are known to influence uterine muscle tone. All of the agents studied to date have been found to produce uterine relaxation. This property has been used to produce therapeutic uterine relaxation for difficult obstetric deliveries and the Ex Utero Intrapartum Treatment (EXIT) procedure. This study describes the effects of sevoflurane on isolated human myometrium at concentrations of 0.1, 0.25, 0.5, 0.75, 1.0, 1.5, 2.5 and 3.5 MAC. Sevoflurane produces dose-dependent depression of uterine muscle contractility with an ED 50 of 0.94 MAC. Frequency of contraction was increased at concentrations of 2.5 MAC and greater. At concentrations of 3.5 MAC and above, uterine activity was virtually abolished.

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0310057X0203000508

Reference33 articles.

1. Intravenous Nitroglycerin for Uterine Relaxation in the Postpartum Patient with Retained Placenta

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4. Intrapartum airway management for giant fetal neck masses: The EXIT (ex utero intrapartum treatment) procedure

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