Neurocognitive Functions in Opioid Dependence: Comparisons Between Opioid Categories-Reference-Cited by-同舟云学术

Neurocognitive Functions in Opioid Dependence: Comparisons Between Opioid Categories

Published:2023-05-30 Issue: Volume: Page:002204262311792
ISSN:0022-0426
Container-title:Journal of Drug Issues
language:en
Short-container-title:Journal of Drug Issues

Author:

Ghosh Abhishek¹^ORCID,Shaktan Alka¹,Verma Abhishek¹²,Nehra Ritu³,Basu Debasish¹^ORCID,Rana Devender K¹,Ahuja Chirag K⁴,Modi Manish⁵,Singh Paramjit⁴

Affiliation:

1. Drug Deaddiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India

2. Department of Psychology, Punjab University, Chandigarh, India

3. Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India

4. Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India

5. Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Abstract

We examined the differences in neurocognitive functions in individuals dependent on heroin ( n = 120), pharmaceutical ( n = 52), and natural opioids ( n = 66) and compared with healthy controls (HC, n = 94). We estimated independent effects of the opioid groups on cognitive tests, adjusted for effect modifiers. Pharmaceutical opioid dependent group performed worse than HC in Wisconsin Card Sorting Test in conceptual level response and trials to complete first category. Pharmaceutical and heroin groups had higher error scores than HC in verbal and visual N-Back Tests (NBTs). There was no significant difference between pharmaceutical and heroin groups, but both had higher error scores than the natural opioid users in NBTs. Time to complete Trail Making- A test was higher in pharmaceutical than in natural opioid group. The natural opioid group required more trials than HC to complete the first category. Pharmaceutical opioid group had worst cognitive impairment. Cognitive functions are relatively spared in natural opioid-dependent group.

Funder

Cognitive Science Research Initiative, Department of Science and Technology, New Delhi, India

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Public Health, Environmental and Occupational Health,Health (social science),Medicine (miscellaneous)

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220426231179208

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