Affiliation:
1. West Midlands Cleft Centre, Birmingham Children's Hospital, Birmingham, UK
2. Department of Paediatric Endocrinology, Birmingham Children's Hospital, Birmingham, UK
Abstract
Objectives Published literature on children with cleft palate and/or lip (CP + /-L) and CHARGE syndrome (CS) is limited. This study investigated cleft characteristics including surgery, and feeding and communication outcomes in children identified with CP + /-L and CS. Design Retrospective cross-sectional review. Setting Regional Referral Centre for Paediatric Cleft Surgery. Patients All children diagnosed with CP + /-L and CS (based on clinical features and/or CHD7 mutation testing) between 1989–2019. Main Outcome Measures Cleft type, timing of CP + /-L repair, reasons for ‘delayed’ repair, feeding methods and communication modality. Results Twenty-two children with CP + /-L and CS were identified. Cleft sub-types (%) were: Eleven (50%) had bilateral cleft lip and palate (BCLP), six (27%) had unilateral cleft lip and palate (UCLP) and five (23%) had cleft palate (CP). Cleft repair was delayed compared to protocol care for non-syndromic children with CP + /-L. Median age for lip repair + /- vomerine flap was 9 months (range 4–22 months), and palate repair was 21 months (range 11–40 months). Median age for isolated CP repair was 13 months (range 7–23). Surgery for cardiac anomalies (36%) before cleft repair, and (59%) were classed as having severe systemic disease at the time of cleft surgery. Only 27% of the children in this study had both full oral feeding and verbal communication. Conclusions Children with CP + /-L and CS had severe cleft types and complex medical problems leading to delayed cleft surgery. Feeding and speech outcomes were better in the children aged over ten years.
Subject
Otorhinolaryngology,Oral Surgery
Cited by
1 articles.
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