Antioxidant profile of constituents isolated from Polygonatumverticillatum rhizomes-Reference-Cited by-同舟云学术

Antioxidant profile of constituents isolated from Polygonatumverticillatum rhizomes

Published:2013-09-30 Issue:1 Volume:32 Page:138-142
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Khan Haroon¹²,Saeed Muhammad³,Muhammad Naveed³,Rauf Abdur⁴,Khan Amir Zada³,Ullah Rooh³

Affiliation:

1. Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan

2. Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan

3. Department of Pharmacy, University of Peshawar, Peshawar, Pakistan

4. Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan

Abstract

The purpose of the current study was to estimate the antioxidant profile of two compounds, diosgenin and santonin, isolated from Polygonatum verticillatum rhizomes. Stable free radical, 2, 2-diphenyl-1-picrylhydrazyl and reducing power assays were employed for this purpose. The results showed profound free radical scavenging effect of both diosgenin and santonin in a concentration-dependent manner. The calculated half maximal inhibitory concentration (IC50) values for both diosgenin and santonin was 65.80 and 50.03 μg/ml, respectively. Similarly, in reducing power assay, diosgenin and santonin exhibited marked quenching effect. The corresponding IC50 values for both the compounds were 62.10 and 46.40 μg/ml, respectively. In conclusion, both the isolated compounds have strong antioxidant potential, which is consistent with the results of the extracts of the plant.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0748233713498454

Reference23 articles.

1. Traditional medicinal plants of cold desert Ladakh—Used against kidney and urinary disorders

2. Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae)

3. Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Non-food natural sesquiterpene lactone α-santonin: Chemistry and biology;Industrial Crops and Products;2024-11

2. In vitro hypoglycemic and antioxidant activities of steamed Polygonatum cyrtonema Hua with various steaming degrees: Relationship with homoisoflavonoids;Food Bioscience;2023-06

3. A depth‐insight on reduced lipolysis of diacylglycerol (DAG) oleogels with the gelation of diosgenin (DSG);International Journal of Food Science & Technology;2023-04-10

4. In-vitro antioxidant, lipoxygenase inhibitory, and in-vivo muscle relaxant potential of the extract and constituent isolated from Diospyros kaki (Japanese Persimmon);Heliyon;2023-03

5. Species of the Genus Polygonatum found in the Western Himalayas;Immunity Boosting Medicinal Plants of the Western Himalayas;2023