Protective effects of zinc and selenium against benzene toxicity in rats-Reference-Cited by-同舟云学术

Protective effects of zinc and selenium against benzene toxicity in rats

Published:2011-04-21 Issue:6 Volume:27 Page:537-545
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Ibrahim Khadiga S¹,Saleh Zeinab A²,Farrag Abdel-Razik H³,Shaban Eman E⁴

Affiliation:

1. Environmental and Occupational Medicine Department, National Research Centre, Dokki, Cairo, Egypt,

2. Food Science and Nutrition Department, National Research Centre, Dokki, Cairo, Egypt

3. Pathology Department, National Research Centre, Dokki, Cairo, Egypt

4. Environmental and Occupational Medicine Department, National Research Centre, Dokki, Cairo, Egypt

Abstract

The presented study investigates the protective role of zinc (Zn) and selenium (Se) in attenuating benzene-induced toxicity in rats. Male Sprague—Dawley rats were injected with benzene (0.5 mL/kg body weight ip) and received a diet supplement containing Zn and Se. Several hematological and biochemical parameters (representing antioxidant status) were estimated. Histopathological examinations were performed. Results showed that food intake and body weight gain of benzene-injected rats were significantly lower than that of the control rats. Benzene-injected rats showed increased plasma malondialdehyde (MDA) and decreased activity of: glutathione peroxidase (GSH-Px), catalase, superoxide dismutase (SOD) enzymes, as well as reduced glutathione (GSH) when compared to the control group. Histopathological investigations revealed structural changes in benzene-injected rats’ liver. Supplementation with Zn and Se resulted in a significant decrease in MDA, elevation in GSH, GSH-Px, SOD and catalase levels. This study shows that Zn and Se supplementation can improve the activity of antioxidant enzymes in rats and decrease the histological anomalies induced by benzene toxicity as well.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0748233710393394

Reference56 articles.

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