Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro-Reference-Cited by-同舟云学术

Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB1 in human lymphocytes in vitro

Published:2011-10-10 Issue:6 Volume:28 Page:505-512
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Aslan Ali¹,Agar Guleray²,Alpsoy Lokman³,Kotan Elif²,Ceker Selcuk²

Affiliation:

1. Department of Biology Teacher Training, Ataturk University, Erzurum, Turkey

2. Department of Biology, Ataturk University, Erzurum, Turkey

3. Department of Biology, Fatih University, Istanbul, Turkey

Abstract

In this study, the antigenotoxic and antioxidant effects of Umbilicaria vellea (UME) and Xantho somloensis (XME) extracts were determined using sister chromatid exchange (SCE), micronuclei (MN) assays, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against the effects of aflatoxin B1 (AFB1)-induced oxidative stress and genotoxicity in human lymphocytes in vitro. The results showed that the frequencies of SCE, MN, and MDA level decreased, but the activities of SOD and GPx increased when 5 μg/mL and 10 μg/mL doses of UME and XME were added to AFB1-treated cultures. Also the present results indicate that strong antioxidative and the antigenotoxicity mechanisms of UME and XME are associated with its antioxidant nature.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0748233711416944

Reference45 articles.

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4. LICHENS FROM THE REGIONS OF ARTVIN, ERZURUM, AND KARS (TURKEY)

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