Protective effects of methanol extracts from Cladonia rangiformis and Umbilicaria vellea against known mutagens sodium azide and 9-aminoacridine

Author:

Gulluce Medine1,Agar Guleray1,Aslan Ali2,Karadayi Mehmet3,Bozari Sedat4,Orhan Furkan5

Affiliation:

1. Department of Biology, Science Faculty, Atatürk University, Erzurum, Turkey

2. Department of Biology, Kazim Karabekir Education Faculty, Atatürk University, Erzurum, Turkey

3. Department of Biology, Science Faculty, Atatürk University, Erzurum, Turkey,

4. Department of Biology, Sciences and Arts Faculty, Mus Alparslan University, Mus, Turkey

5. Institute of Natural and Applied Sciences, Atatürk University, Erzurum, Turkey

Abstract

Lichens and their various extracts have been occasionally used in the treatment of many diseases. Cladonia rangiformis and Umbilicaria vellea are two important species of these lichens and they have several biological activities. In the present study, methanol extracts of these lichens, which are grown in the Eastern Anatolia Region of Turkey, were isolated, and their mutagenic and antimutagenic properties were investigated by using AMES-Salmonella and Zea mays Root Tip Mitotic Index mutagenicity and antimutagenicity assay systems. Known mutagens sodium azide (NaN3) and 9-Aminoacridine (9-AA) were used to determine antimutagenic properties of methanol extracts. The results showed that all methanol extracts, investigated in the present study, can be considered genotoxically safe because they do not have mutagenic activity at the tested concentrations. Besides, all of them have antimutagenic activity against 9-AA known as a model intercalator agent in the AMES-Salmonella test system. The inhibition rates obtained from the antimutagenicity assays ranged from 37.07% (C. rangiformis—5 µg/plate) to 54.39% (C. rangiformis—5 µg/plate). Furthermore, all the methanol extracts have significant antimutagenic activity against NaN3 mutagenicity in Z. mays Root Tip Mitotic Index assay system. These activities are valuable towards an extension of the employ of these drugs as new phytotherapeutic or preservative ingredients.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

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