Measuring pure ground-glass nodules on computed tomography: assessing agreement between a commercially available deep learning algorithm and radiologists’ readings

Abstract

Background Deep learning algorithms (DLAs) could enable automatic measurements of solid portions of mixed ground-glass nodules (mGGNs) in agreement with the invasive component sizes measured during pathologic examinations. However, the measurement of pure ground-glass nodules (pGGNs) based on DLAs has rarely been reported in the literature. Purpose To evaluate the use of a commercially available DLA for the automatic measurement of pGGNs on computed tomography (CT). Material and Methods In this retrospective study, we included 68 patients with 81 pGGNs. The maximum diameter of the nodules was manually measured by senior radiologists and automatically segmented and measured by the DLA. Agreement between the measurements by the radiologist and DLA was assessed using Bland–Altman plots, and correlations were analyzed using Pearson correlation. Finally, we evaluated the association between the radiologist and DLA measurements and the invasiveness of lung adenocarcinoma in patients with pGGNs on preoperative CT. Results The radiologist and DLA measurements exhibited good agreement with a Bland-Altman bias of 3.0%, which were clinically acceptable. The correlation between both sets of maximum diameters was also strong, with a Pearson correlation coefficient of 0.968 ( P < 0.001). In addition, both sets of maximum diameters were larger in the invasive adenocarcinoma group than in the non-invasive adenocarcinoma group ( P < 0.001). Conclusion Automatic pGGNs measurements by the DLA were comparable with those measured manually and were closely associated with the invasiveness of lung adenocarcinoma.