Unravelling pituitary tumours in medically treated patients with acromegaly: the impact of systematic MRI reassessment

Author:

Atai Shahriar12ORCID,Knudtzon Andersen Martin34,Wiedmann Markus5,Dahlberg Daniel5,Øystese Kristin Astrid B1,Bollerslev Jens2,Ringstad Geir36,Heck Ansgar1ORCID

Affiliation:

1. Department of Endocrinology, Oslo University Hospital, Oslo, Norway

2. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

3. Department of Radiology, Oslo University Hospital, Oslo, Norway

4. Department of Radiology, Diakonhjemmet Hospital, Oslo Norway

5. Department of Neurosurgery, Oslo University Hospital, Oslo, Norway

6. Department of Geriatrics and Internal medicine, Sorlandet Hospital, Arendal, Norway

Abstract

Background In acromegaly, the primary tumor is usually found during magnetic resonance imaging (MRI) of the pituitary gland. A remnant tumor after surgery is, however, harder to depict. When a tumor is missed, the remaining option is usually lifelong pharmacological treatment. Purpose To identify tumors by reassessment of all available MRI scans in pharmacologically treated patients, operated or not, and to compare our results with the routine MRI reports. Material and Methods Adult patients diagnosed with acromegaly and managed at a tertiary care center between 2005 and 2021 and currently on pharmacological treatment were included. MRI scans were evaluated in a standardized manner and classified independently by a radiologist and an endocrinologist into “certain,” “suspected,” or “no tumor.” In case of disagreement, consensus was achieved with a senior neuroradiologist. The results were compared using the clinical radiologists’ routine MRI reports. Results We identified certain and suspected tumors in 29/74 and 36/74 patients, respectively. No tumor was identified in nine patients. In five of these, no MRI contrast agent was given. Discrepancy between our results and the routine MRI reports was found in 31/74 patients ( P = 0.01). In 22 patients, the routine reports described no tumor while we identified certain tumors in 2/22 patients and suspected tumors in 13/22 patients. Conclusion In most patients with pharmacologically treated acromegaly, we identified a certain or suspected pituitary tumor. These findings were more frequent compared to the routine MRI reports. Based on our results, patients will be considered for a change in long-term treatment modality.

Funder

Helse Sør-Øst RHF

Publisher

SAGE Publications

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3