Review: Airway smooth muscle as a model for new investigative drugs in asthma-Reference-Cited by-同舟云学术

Review: Airway smooth muscle as a model for new investigative drugs in asthma

Published:2008-06 Issue:3 Volume:2 Page:129-139
ISSN:1753-4666
Container-title:Therapeutic Advances in Respiratory Disease
language:en
Short-container-title:Ther Adv Respir Dis

Author:

Baroffio Michele¹,Crimi Emanuele¹,Brusasco Vito²

Affiliation:

1. Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

2. Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy,

Abstract

Bronchial asthma as such exists because airway smooth muscle (ASM) contracts excessively in response to various stimuli. After several decades during which research was mainly focused on airway inflammation, increasing attention is now being paid to a possible abnormal behaviour of ASM. Thus, ASM is regarded as a major target for anti-asthma treatments. This review first describes the mechanisms of ASM contraction and airway hyperresponsiveness, through cellular, animal and human models. The developments of new drugs targeting extra and/or intracellular pathway of ASM contraction are discussed.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Pulmonary and Respiratory Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1753465808091154

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