Prognostic Value of Podoplanin in Various Tumors-Reference-Cited by-同舟云学术

Prognostic Value of Podoplanin in Various Tumors

Published:2021-01-01 Issue: Volume:20 Page:153303382110381
ISSN:1533-0346
Container-title:Technology in Cancer Research & Treatment
language:en
Short-container-title:Technol Cancer Res Treat

Author:

Wang Xiaohang¹²,Wang Xueying³²,Carvalho Vladmir¹,Wang Qianqian¹,Li Tingting¹,Wang Jinbang¹,Chen Yang¹,Ni Chengming¹,Liu Subo⁴,Zhang Jiaxin³

Affiliation:

1. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China

2. Xiaohang Wang and Xueying Wang contributed equally to this article

3. Department of Breast and Thyroid Surgery, Yangzhou University Affiliated Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China

4. Department of Endocrinology, Shijiazhuang First Hospital, Shijiazhuang, China

Abstract

Background: The prognostic significance of podoplanin (PDPN) in tumor cells for cancer patients’ survival remains controversial. Therefore, we performed this meta-analysis to clarify the relationship between the podoplanin-positive tumor cells and cancer prognosis. Method: Eligible studies were identified by searching the Pubmed and EBSCO online databases up to August 2019. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the correlation between podoplanin expression and overall survival (OS) and/or disease-free survival (DFS) and odds ratios (ORs) with 95% CIs severed as the summarized statistics for clinicopathological characteristic. Results: A total of 2155 patients from 21 eligible studies were included. The results revealed that high expression of podoplanin was associated with a poor survival rate in cancer patients. Further subgroup analysis stratified by tumor type showed that podoplanin-positive tumor cell infiltration had a negative prognostic effect associated with survival in esophageal cancer and oropharyngeal cancer. In addition, high expression of these cells was significantly associated with N stage, T stage, TNM stage and vascular invasion. Conclusion: Our study suggests the over-expression of podoplanin might be a significant prognostic indicator for patients with esophageal and oropharyngeal cancer.

Funder

National Nature Science Foundation of China

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/15330338211038142

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