5-Carbohydrazide and 5-carbonylazide of pyrazolo[3,4-b]pyridines as reactive intermediates in the synthesis of various heterocyclic derivatives-Reference-Cited by-同舟云学术

5-Carbohydrazide and 5-carbonylazide of pyrazolo[3,4-b]pyridines as reactive intermediates in the synthesis of various heterocyclic derivatives

Published:2019-07 Issue:7-8 Volume:43 Page:219-229
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Aly Ashraf A¹^ORCID,El-Emary Talaat I²,Mourad Aboul-Fetouh E¹,Khallaf Alyan Zainab¹,Bräse Stefan³,Nieger Martin⁴

Affiliation:

1. Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt

2. Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

3. Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany

4. Department of Chemistry, University of Helsinki, Helsinki, Finland

Abstract

5-Carbohydrazides and 5-carbonylazides of pyrazolo[3,4- b]pyridines are used to synthesize new heterocyclic derivatives. Some unexpected behaviors are observed in the reactions of the above two species. The structures of the obtained compounds are proved by spectroscopic studies together with elemental and X-ray structure analyses.

Funder

deutsche forschungsgemeinschaft

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/1747519819861625

Reference25 articles.

1. Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction

2. Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses

3. New orally active PDE4 inhibitors with therapeutic potential