Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
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Published:2019-01
Issue:
Volume:6
Page:204993611986802
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ISSN:2049-9361
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Container-title:Therapeutic Advances in Infectious Disease
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language:en
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Short-container-title:Therapeutic Advances in Infection
Author:
Roc Lourdes1, de Mendoza Carmen2, Fernández-Alonso Miriam3, Reina Gabriel3, Soriano Vicente4ORCID, Rodríguez C., Vera M., del Romero J., Marcaida G., Ocete M.D., Caballero E., Molina I., Aguilera A., Rodríguez-Calviño J.J., Navarro D., Rivero C., Vilariño M.D., Benito R., Algarate S., Gil J., Ortiz de Lejarazu R., Rojo S., Eirós J.M., San Miguel A., Manzardo C., Miró J.M., García J., Paz I., Poveda E., Calderón E., Escudero D., Trigo M., Diz J., García-Campello M., Rodríguez-Iglesias M., Hernández-Betancor A., Martín A.M., Ramos J.M., Gimeno A., Gutiérrez F., Rodríguez J.C., Sánchez V., Gómez-Hernando C., Cilla G., Pérez-Trallero E., López-Aldeguer J., Fernández-Pereira L., Niubó J., Hernández M., López-Lirola A.M., Gómez-Sirvent J.L., Force L., Cifuentes C., Pérez S., Morano L., Raya C., González-Praetorius A., Pérez J.L., Peñaranda M., Hernáez-Crespo S., Montejo J.M., Roc L., Martínez-Sapiña A., Viciana I., Cabezas T., Lozano A., Fernández J.M., García-Bermejo I., Gaspar G., García R., Górgolas M., Vegas C., Blas J., Miralles P., Valeiro M., Aldamiz T., Margall N., Guardia C., do Pico E., Polo I., Aguinaga A., Ezpeleta C., Sauleda S., Pirón M., González R., Barea L., Jiménez A., Blanco L., Suárez A., Rodríguez-Avial I., Pérez-Rivilla A., Parra P., Fernández M., Fernández-Alonso M., Reina G., Treviño A., Requena S., Benítez-Gutiérrez L., Cuervas-Mons V., de Mendoza C., Barreiro P., Soriano V., Corral O., Gómez-Gallego F.,
Affiliation:
1. Microbiology Department, Hospital Miguel Servet, Zaragoza 2. Puerta de Hierro Research Institute and University Hospital, Majadahonda, Madrid, Spain 3. Microbiology Department, Clinica Universitaria, Pamplona 4. UNIR Health Sciences School, Calle Almansa 101, Madrid, 28040, Spain
Abstract
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor–recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
Publisher
SAGE Publications
Subject
Pharmacology (medical),Infectious Diseases
Cited by
11 articles.
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