Effect of Alaska pollock-gelatin sheet on repair strength and regeneration of nerve-Reference-Cited by-同舟云学术

Effect of Alaska pollock-gelatin sheet on repair strength and regeneration of nerve

Published:2024-05-23 Issue: Volume: Page:
ISSN:1753-1934
Container-title:Journal of Hand Surgery (European Volume)
language:en
Short-container-title:J Hand Surg Eur Vol

Author:

Tsujisaka Ryosuke¹,Suzuki Taku¹^ORCID,Shibata Shinsuke²,Iwamoto Takuji¹,Taguchi Tetsushi³⁴,Nakamura Masaya¹

Affiliation:

1. Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan

2. Electron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan

3. Graduate School of Pure and Applied Sciences, University of Tsukuba, Ibaraki, Japan

4. Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, Ibaraki, Japan

Abstract

The aim of the study was to investigate the repair strength and the biocompatibility of Alaska pollock-derived gelatin (ApGltn) sheet for nerve repair. Cadaveric digital nerves were repaired with double suture, single suture + ApGltn sheet, single suture + fibrin glue, single suture, ApGltn sheet and fibrin. Maximum failure loads were measured (20 nerves each). Rat sciatic nerves were repaired with double suture, single suture + ApGltn sheet, single suture, ApGltn sheet, fibrin glue and resection (10 nerves each). Macroscopic appearance, muscle weight and histopathological findings were examined 8 weeks postoperatively. The mean failure load of ApGltn sheet (0.39 N) was significantly higher than that of a fibrin (0.05 N), and that of single suture + ApGltn sheet (1.32 N) was significantly higher than that of a single suture alone (0.97 N). Functional and histological assessments showed similar nerve recovery among the suture, ApGltn and fibrin groups. ApGltn sheet has potential for clinical application as an alternative to fibrin.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/17531934241251670

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