Is Dupuytren’s disease really a ‘disease of the Vikings’?

Author:

Ng Michael1,Lawson Daniel J2,Winney Bruce3,Furniss Dominic14

Affiliation:

1. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Oxford, UK

2. Integrative Epidemiology Unit, University of Bristol, Bristol, UK

3. Department of Oncology, University of Oxford, Oxford, UK

4. NIHR Biomedical Research Centre, University of Oxford, Oxford, UK

Abstract

It has been suggested that Dupuytren’s disease has an origin in Norse countries. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. We computed Wright’s Fixation Index between Orkney (Norse ancestry), Wales (ancient British) and South East England (Anglo-Saxons); compared mean Wright’s Fixation Index in cases versus controls; used permutation to determine any excess of Norse inheritance in disease associated variants; constructed a genetic risk score for Dupuytren’s disease and applied this to the People of the British Isles dataset to look for systematic differences between counties with known high and low levels of Norse ancestry. Finally, chromosome painting was used to see whether Dupuytren’s disease-associated single nucleotide polymorphisms are geographically structured. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren’s disease. We conclude that there is no genetic evidence for a ‘Viking origin of Dupuytren’s disease’.

Publisher

SAGE Publications

Subject

Surgery

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals;Molecular Biology and Evolution;2023-06-01

2. Skin Closure After Subtotal Aponeurectomy in Severe Dupuytren’s Contracture: Review;Traumatology and Orthopedics of Russia;2022-06-28

3. Vitamin D status in Dupuytren's disease: Association with clinical status and vitamin D receptor expression;Journal of Plastic, Reconstructive & Aesthetic Surgery;2022-06

4. Fibrotic diseases;Wound Healing, Fibrosis, and the Myofibroblast;2022

5. Wieso gerade ich? Ursachen und Risikofaktoren;Morbus Dupuytren;2022

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3