Stage I Melanoma of the Limbs: Assessment of Prognosis by Levels of Invasion and Maximum Thickness-Reference-Cited by-同舟云学术

Stage I Melanoma of the Limbs: Assessment of Prognosis by Levels of Invasion and Maximum Thickness

Published:1978-06 Issue:3 Volume:64 Page:273-284
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Breslow Alexander¹,Cascinelli Natale²,Van Der Esch Eric P.³,Morabito Alberto⁴,Kraevski N.⁵,Giordano G. G.⁶,Golbert Z. V.⁷,Van Der Esch E.⁸,Costa De Queiroz⁹,Prade M.¹⁰,Verhest A.¹¹,Pizzetti F.¹²,Efskind J.¹³,Raitchev R.¹⁴,Urban ¹⁵,Niepolomska W.¹⁶,Dabska M.¹⁷,Svejda J.¹⁸,Blinova A.¹⁹,Sugar J.²⁰,

Affiliation:

1. Professor of Pathology, The George Washington University, Medical Center, Washington, D.C., U.S.A.

2. Associate Director, Division of Clinical Oncology G, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

3. Pathologist, Het Nederlands Kankerinstituut Amsterdam, The Netherlands

4. Statistician, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

5. Cancer Research Centre of the U.S.S.R. Academy of Medical Sciences, Moscow, U.S.S.R.

6. Istituto Nazionale per lo Studio e la Cura dei Tumori « Fondazione Pascale », Naples, Italy

7. Herzen State Oncological Institute, Moscow, U.S.S.R.

8. Het Nederlands Kankerinstituut, Amsterdam, The Netherlands

9. Hospital A. C. Camargo, Sao Paolo, Brazil; Head of the Department of Pathologists, Instituto Nacional de Enfermedades Neoplasticas, Lima, Perù

10. Institut Gustave Roussy, Villejuif, France

11. Institut Jules Bordet, Brussels, Belgium

12. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

13. Norwegian Radium Hospital, Oslo, Norway

14. Oncological Research Institute, Sofia, Bulgaria

15. Oncological Institute, Cracow, Poland

16. Oncological Institute, Gliwice, Poland

17. Oncological Institute, Warsaw, Poland

18. Oncological Institute, Brno, Czechoslovakia

19. Petrov Research Institute of Oncology, Leningrad, U.S.S.R.

20. State Institute of Oncology, Budapest, Hungary.

Abstract

The prognostic significance of 2 histological parameters, level of invasion and maximum thickness is evaluated in 248 cases of malignant melanoma of the limbs staged T1–3, N0 M0 which were collected for Trial No. 1 of the W.H.O. Collaborating Centres for the Evaluation of Methods of Diagnosis and Treatment of Melanoma between September 1967 and December 1974. There is a linear relation of tumor thickness to mortality with a high statistical significance (P = 0.0002). Mortality also increases with progression of the level of invasion. The incidence of occult metastases to the regional lymph nodes increases with increasing thickness or level of invasion. Moreover the age and sex corrected survival curves are also dependent on both parameters. The comparison of the 2 methods revealed that maximal tumor thickness is a more powerful measure of prognosis than is the determination of the level of invasion.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089167806400305

Reference14 articles.

1. Tumor Thickness, Level of Invasion and Node Dissection in Stage I Cutaneous Melanoma

2. Long Term Results of Surgical Treatment of Melanoma of the Limbs

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