Tamoxifen Therapy in Advanced Breast Cancer with Positive Estrogen Receptors in Postmenopausal Women

Abstract

Sixty-five postmenopausal patients with metastatic or surgically unresectable primary breast cancer, all estrogen receptor (ER) positive, were treated with tamoxifen 20–40 mg a day. Overall objective response rate was 58%, with a median duration time of 13 months. The correlation between response rate and ER levels appears positive, although not statistically significant. The analysis of the data was also performed in the subgroups « locally advanced tumors » and « recurrences and metastases ».