Efficacy of Urokinase and Alteplase to Reopen Occluded Central Venous Catheters in Children-Reference-Cited by-同舟云学术

Efficacy of Urokinase and Alteplase to Reopen Occluded Central Venous Catheters in Children

Published:2001-05 Issue:3 Volume:17 Page:95-98
ISSN:8755-1225
Container-title:Journal of Pharmacy Technology
language:en
Short-container-title:Journal of Pharmacy Technology

Author:

Bussières Jean-François¹,Therrien Roxane²,David Michèle³,Leclair Jean-Pierre⁴,Harel François⁵

Affiliation:

1. JEAN-FRANÇOIS BUSSIÈRES BPharm MSc MBA, Director, Department of Pharmacy, Hôpital Ste-Justine, Université de Montréal, Montréal, Québec, Canada

2. ROXANE THERRIEN, BPharm Student, Research Assistant, Department of Pharmacy, Hôpital Ste-Justine

3. MICHÈLE DAVID MD, Hemato-oncologist, Department of Pediatrics, Division of Hematology—Oncology, Hôpital Ste-Justine

4. JEAN-PIERRE LECLAIR BPharm MSc, Clinical Pharmacist, Department of Pharmacy, Hôpital Ste-Justine

5. FRANÇOIS HAREL MSc, Biostatistician, Department of Biostatistics, Montréal Heart Institute, Montréal

Abstract

Objective: To compare the efficacy of alteplase with that of urokinase (UK) in restoring the patency of occluded central venous catheters in children. Study Design: Retrospective case–control study at Hôpital Ste-Justine, a pediatric teaching hospital. Results: 87 UK and 46 alteplase prescriptions were studied. Alteplase was effective in 93.2% of cases of occluded central venous catheters and UK in 54.5% of cases (p < 0.001). Conclusions: Alteplase was clearly superior to UK for restoring the patency of occluded central venous catheters in children. The study is limited by its retrospective design.

Publisher

SAGE Publications

Subject

Pharmaceutical Science

Link

http://journals.sagepub.com/doi/pdf/10.1177/875512250101700304

Reference21 articles.

1. Silastic cuffed catheters for hemodialysis vascular access: Thrombolytic and mechanical correction of malfunction

2. Restoring Patency of Occluded Central Venous Catheters

3. Guidelines for antithrombotic therapy in pediatric patients

4. Mechanism of Action of Plasminogen Activators

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