Orotracheal treprostinil administration attenuates bleomycin‐induced lung injury, vascular remodeling, and fibrosis in mice

Author:

Nikitopoulou Ioanna1,Manitsopoulos Nikolaos1,Kotanidou Anastasia12,Tian Xia3,Petrovic Aleksandar3,Magkou Christina4,Ninou Ioanna5,Aidinis Vassilis5,Schermuly Ralph T.3,Kosanovic Djuro36,Orfanos Stylianos E.127

Affiliation:

1. GP Livanos and M Simou Laboratories1st Department of Critical Care & Pulmonary ServicesMedical SchoolNational & Kapodistrian University of AthensEvangelismos HospitalAthensGreece

2. 1st Department of Critical Care & Pulmonary ServicesMedical SchoolNational & Kapodistrian University of AthensEvangelismos HospitalAthensGreece

3. Universities of Giessen and Marburg Lung CenterMember of the German Center for Lung Research (DZL)Justus‐Liebig UniversityGiessenGermany

4. Department of PathologyEvangelismos HospitalAthensGreece

5. Institute of ImmunologyBiomedical Sciences Research Center Alexander FlemingAthensGreece

6. Sechenov First Moscow State Medical University (Sechenov University)MoscowRussia

7. 2nd Department of Critical CareMedical SchoolNational & Kapodistrian University of Athens“Attikon” HospitalHaidariAthensGreece

Funder

United Therapeutics Corporation

Galenica-Ferrer

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

Reference61 articles.

1. Diagnostic and prognostic challenges in Idiopathic pulmonary fibrosis: a patient's “Q and A” approach;Tzouvelekis A;Pulm Pharmacol Ther,2017

2. Idiopathic pulmonary fibrosis: treatment and prognosis;Fujimoto H;Clin Med Insights Circul Respir Pulm Med,2015

3. A Systematic review of the role of dysfunctional wound healing in the pathogenesis and treatment of idiopathic pulmonary fibrosis;Betensley A;J Clin Med,2016

4. Pulmonary hypertension in chronic lung disease and hypoxia;Nathan SD;Eur Respir J,2019

5. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis;Richeldi L;N Engl J Med,2014

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